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"The mission of the Epilepsy Foundation is to lead the fight to overcome the challenges of living with epilepsy and to accelerate therapies to stop seizures, find cures, and save lives."

 

What To Do If Your Medication Stops Working

What If Your Medication Stops Working

For many individuals living with epilepsy, anti-seizure medications (ASMs) provide effective seizure control. However, in some cases, medications that were once effective may become less effective over time. This phenomenon, known as drug resistance or refractory epilepsy, can be concerning and may require adjustments to your treatment plan. If you suspect your medication is no longer working, there are several important steps to take to regain control over your seizures.

Identify Possible Causes

Several factors can contribute to a decrease in medication effectiveness, including:

  • Missed or Incorrect Doses: Skipping doses, taking medication inconsistently, or incorrect dosing can lead to breakthrough seizures.
  • Changes in Metabolism: Your body’s ability to absorb and process medication can change over time due to factors like weight fluctuations, aging, or other health conditions.
  • Drug Interactions: New medications, supplements, or even certain foods can interfere with how your ASM is absorbed and processed.
  • Increased Seizure Triggers: Stress, sleep deprivation, hormonal changes, or illness may increase seizure susceptibility.
  • Progression of Epilepsy: In some cases, epilepsy itself can change, requiring a new or adjusted treatment approach.

Consult Your Healthcare Provider

If you notice an increase in seizures despite taking your medication as prescribed, schedule an appointment with your neurologist or epilepsy specialist. They may:

  • Review your medical history and recent seizure activity.
  • Adjust your medication dosage to optimize effectiveness.
  • Conduct blood tests to check medication levels.
  • Evaluate for possible drug interactions or underlying conditions.
  • Recommend switching to a different ASM or adding a second medication.

Explore Alternative Treatment Options

If medication adjustments do not restore seizure control, other treatment options may be considered, such as:

  • Ketogenic or Modified Diets: High-fat, low-carbohydrate diets have been effective for some individuals with drug-resistant epilepsy.
  • Vagus Nerve Stimulation (VNS): A device implanted under the skin sends electrical impulses to help reduce seizures.
  • Responsive Neurostimulation (RNS): This device monitors brain activity and provides targeted stimulation to prevent seizures.
  • Surgical Options: In some cases, epilepsy surgery may be an option if seizures originate from a specific area of the brain.

Maintain a Seizure Diary

Keeping a detailed record of your seizures, medication schedule, and potential triggers can provide valuable insights for your doctor. Note the date, time, duration, and any symptoms before and after each seizure, as well as any lifestyle changes that could be affecting seizure activity.

Do Not Stop Medication Abruptly

If your medication seems ineffective, it may be tempting to stop taking it. However, stopping medication suddenly can lead to increased seizures and withdrawal effects. Always consult your doctor before making any changes to your medication regimen.

If your epilepsy medication stops working, it is crucial to act quickly by identifying potential causes, consulting your doctor, and exploring alternative treatment options. With the right approach, many individuals regain seizure control and continue to live full, active lives. Regular follow-ups, careful medication management, and lifestyle adjustments can help ensure your treatment remains effective over time.

Text generated by ChatGPT, March 8, 2025, OpenAI, https://chat.openai.com/chat. ChatGPT